AgeDefi Cellulite, a mesotherapy-based programme from Dr Nyjon Eccles (£1,620 for 12 treatments, www.chironclinic.com, 020 7224 4622). Or, DIY and zap your own thighs with TriPollar POSE (£349 .... Press Onward. Make leg presses a part of your workout and you'll lose thigh fat and enjoy greater muscle definition in no time. Seated leg presses can help work your hamstrings, butt, quads, and calves, increasing your metabolism with every pound of muscle you build. Fortunately, you don't have to add tons of weight to your routine to achieve.